Computers and DNA
Table of Contents
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Edited by George I. Bell and Thomas G. Marr
Preface
Introductory
The Human Genome: An Introduction
Computation and the Human Genome Project: An Historical Perspective
Charles DeLisi
What We Have Learned and Will Learn from Sequence Data Bases
Databases
The Flow of Nucleotide Sequence Data into Data Banks: Role and Impact of Large-Scale Sequencing Projects
DNA Data Bank of Japan: Present Status and Future Plans
BIONET: Status and Future Plans
The Human Gene Mapping Library: Present Status and Future Directions
J. Claiborne Stephens, Iva H. Cohen, and Kenneth K. Kidd Sequence Comparisons
High-Efficiency Sequence Database Searching: Use of the Distributed Array Processor
Sequence Searching of Supercomputers
Protein Sequence Comparison on the Connection Machine CM-2
Robert Jones, Washington Taylor IV, Xiru Zhang, Jill P. Mesirov, and Eric Lander
Computation of d squared: A Measure of Sequence Dissimilarity
Multiple Hypothesis Testing for Sequence Comparisons
Analysis
Superhelical Transitions and DNA Regulation
Non-Continuous Patterns and Compositional Complexity of Nucleic Acid Sequences
Application of Neural Networks and Other Machine Learning Algorithms to DNA Sequence Analysis
CPGA: A Prototype for Analysis of the Sequence-Structure Function Relationship in the Human Genome Project
Statistical Analysis of Nucleic Acid Sequences
GeneSys: A Knowledge Management System for Molecular Biology
G. Christian Overton, Kimberle Koile, and Jon A. Pastor
Simulation and Analysis of Physical Mapping
Genetic Sequence Semantic and Syntactic Patterns
Index
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