Edited by Alan S. Perelson

Part One

Foreword
A. S. Perelson

Cell Stimulation and Receptor Crosslinking

Desensitization, Histamine Release and the Aggregation of IgE on Human Basophils
B. Goldstein

Progress Toward Understanding the Molecular Details and Consequences of IgE-Receptor Crosslinking
B. Baird, J. Erickson, B. Goldstein, P. Kane, A. K. Menon, D. Robertson, and D. Holowka

Two Distinct States of Crosslinked IgE Receptors that May Trigger and Terminate Secretion from RBL-2H3 Mast Cells
J. M. Oliver, J. C. Seagrave, and R. F. Stump

A Molecular Basis for Immune Regulation: The Immunon Hypothesis
H. M. Dintzis and R. Z. Dintzis

Cell-Cell Adhesion Resembles Receptor Crosslinking
G. I. Bell

B Cell Clonogenesis Induced by Anti-Immunoglobulin (Anti-IG) and Interleukins
G. D. Wetzel

Antigen Presentation and the Structure of Antigenic Determinants

Where Did the Macrophage Get the Antigen From?
J. Ninio

Statistics in Immunology and Biochemistry: An Application to T Cell Antigenic Sites
J. L. Spouge and J. A. Berzofsky

Hydrophilicity, Solvent Accessibility and Location of Antigenic Determinants in Proteins
P. Klein and R. L. Somorjai

Dynamics of the Immune Response

The Regulation of Lymphocyte Proliferation by Proliferating Lymphocytes: Is Lactate a Central Regulatory Element in the Immune System?
W. Droge

Modeling Dynamical Aspects of the Immune Response: I. T Cell Proliferation and the Effect of IL-2
I. G. Kevrekidis, A. D. Zecha, and A. S. Perelson

Role of Multistability in an Immune Response Model: A Combined Discrete and Continuous Approach
M. Kaufman

Systematic Approach to Modeling Immune Response
J. Eisenfeld and P. Prueitt

The Flow Topology of the Herzenberg Immunological Control Networks
R. B. King

A Logical Dynamic Systems Approach to the Regulation of Antigen-Driven Lymphocyte Stimulation
H. B. Sieburg

Decision Criteria and Coherence in the Regulation of the Immune Response
P. A. Bretscher

Antibody Affinity Distribution-Based Models for Vaccine Potency
P. J. Hingley

On Immune Process Stochastic Structure
R. R. Mohler and Z. H. Farooqi

Maturation of the Immune Response

Maturation of the Immune Response via Adaptive Walks on Affinity Landscapes
S. A. Kauffman, E. D. Weinberger, and A. S. Perelson

Affinity Maturation and Ecological Succession: An Analogy Suggested by Computer Modeling
R. G. Weinand and M. Conrad

Index

Part Two

Foreword
A. S. Perelson

Immune Surveillance

How Immune Cells Find Their Targets: Quantitative Studies of Cell Adhesion, Migration, and Chemotaxis
D. Lauffenburger, D. Hammer, R. Tranquillo, H. Buettner, and E. Fisher

Population Dynamics of Tumors Attacked by Immunocompetent Killer Cells
J. R. Hiernaux and R. Lefever

Immune Surveillance: Towards a Tumor-Specific Model
S. Michelson

Mathematical Models of HIV Infection

AIDS: Background and the Dynamics of the Decline of Immunocompetence
S. Merrill

HIV Infection from an Ecological Viewpoint
A. McLean

Analysis of Immune System Retrovirus Equations
N. Intrator, G. P. Deocampo, and L. N. Cooper

Complexities of Antigen-Antibody Systems

Models of Immunolysis Assays: A Vesicle-Based Approach for Direct Binding
B. A. Waite and E. L. Chang

Pseudo-Cooperativity Resulting from Ring Closure in Divalent Antibody-Divalent Antigen Interactions
A. Gandolfi and R. Strom

Estimation of Antibody Affinity via Reduced Order Modeling
C. S. Hsu

Symbolic Interpretation of Data and the Definition of Factors in Immunogenetics
A. Wohlgemuth

Immune Suppression and Self-Tolerance

Idiotypic Control of the Immune Response to Ferrodoxin
J. North, N. R. Chu, A. Chan, J. K. Steele, R. Singhai, A. T. Strammers, and J. G. Levy

Predominate Use of the Particular V Gene in the KLH-Specific Suppressor T Cell Family
M. Taniguchi, K. Imai, and H. Koseki

The Role of I-J+ Macrophages in the Induction of Antigen B-Specific T-Suppressor Cells
A. Malley and S. M. Shiigi

Control of Lethal Autoreactivity Without a Network
H.-G. Rammensee

Idiotypic Networks

Categories of Idiotype Overlap and Anti-Idiotypic Mimicry of Antigen
N. S. Greenspan and K. H. Roux

In Search of T-Cell Help for the Internal Image of the Antigen
F. Celada

Symmetry and Asymmetry in the Immune Network
V. G. Nesterenko

Symmetric Idiotypic Networks: Connectance and Switching, Stability, and Suppression
R. J. De Boer

The N-Dimensional Network
G. W. Hoffmann, T. A. Kion, R. B. Forsyth, K. G. Saga, and A. Cooper-Willis

Computations in Shape Space: A New Approach to Immune Network Theory
L. A. Segel and A. S. Perelson

Polydispersity in Immune Networks
J. K. Percus

Cognitive Networks: Immune, Neural, and Otherwise
J. K. Percus

Toward a Realistic Model of the Immune System
A. S. Perelson

Index