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Aging and Adaptation in Infectious Diseases III

  • About
  • Program
  • Participants
  • Summary
Tuesday, January 14, 2020
8:30 am - 9:00 am Day 1 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 9:30 am Welcome, Introductions and Workshop Overview - Jean Carlson (UCSB), Mercedes Pascual (Univ. Chicago)
 
9:30 am - 12:00 pm Session I: Immune System: Innate/Adaptive collaboration

(20 minute presentations+10 minute discussion; general discussion at the end)   

Moderator: Mercedes Pascual

  1. Fast & Slow Immunology: Can we frame predictable temporal trajectories in immunity? Review and Perspectives A - Micaela Martinez (Columbia Univ.)
  2. Review and Perspectives B - Andrea L. Graham (Princeton)
  3. Immunosenosence in Coupled Models of Innate/Adaptive Immune Responses A - Jean Carlson (UCSB), Eric Jones (UCSB)
  4. Immunosenosence in Coupled Models of Innate/Adaptive Immune Responses B - Shenshen Wang (UCLA), Jiming Sheng (UCLA)
12:00 pm - 1:00 pm Day 1 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 3:30 pm Session II: Diversity, adaptive immunity, and age

(20 minute presentations+10 minute discussion; general discussion at the end)

Moderator: Jean Carlson   

  1. Allometically scaled immune response - Andrew P. Dobson (Princeton), Chris Kempes (SFI)
  2. Immune imprinting and antigenic maps revisited - Sarah Cobey (Univ. Chicago), Pamela Martinez (Harvard), Katie Gostic (UCLA)
  3. Frequency-dependent selection and prediction of strain dynamics in a bacterial pathogen - Pamela Martinez (Harvard)
  4. Diversity threshold and epidemiological models for parasites with extreme antigenic variation - Mercedes Pascual (Univ. Chicago), Qixin He (Univ. Chicago)
3:30 pm - 4:00 pm Day 1 PM Break
 
4:00 pm - 5:00 pm Day 1 Discussion, development of themes, and structure of breakout groups for the rest of the week
 
6:00 pm Group Dinner
 
Wednesday, January 15, 2020
8:30 am - 9:00 am Day 2 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 11:00 am Session III: Disease History, Aging, and Complex Time

(20 minute presentations+10 minute discussion; 30 minutes general discussion at the end)

Moderator: Mercedes Pascual   

  1. How many diseases can one pathogen cause - the shape of disease responses in mice as a species - David Schneider (Stanford)
  2. Identifying variants from influenza A H1N1 that exhibit birth-cohort immune escape signatures - Katia Koelle (Emory Univ.)
  3. The Tempo of Our Planet: Biological Rhythms & Health - Micaela Martinez (Columbia Univ.)
11:00 am - 12:00 pm Day 2 Group Discussion and Working Group Planning Sessions
 
12:00 pm - 1:00 pm Day 2 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 2:30 pm Discussion: Plans for an SFI publication / Presentation from SFI Press
 
2:30 pm - 4:30 pm Day 2 Working Group Breakout Sessions
 
4:30 pm - 5:00 pm Re-assembling: Brief updates and plans for Day 3
 
Thursday, January 16, 2020
8:30 am - 9:00 am Day 3 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 12:00 pm Day 3 Working Group Breakout Sessions I
 
12:00 pm - 1:00 pm Day 3 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 3:00 pm Day 3 Working Group Breakout Sessions II
 
3:00 pm - 3:30 pm Day 3 PM Break
 
3:30 pm - 5:00 pm Day 3 Working Group Breakout Sessions III
 
Friday, January 17, 2020
8:30 am - 9:00 am Day 4 Continental Breakfast (outside Noyce Conference Room)
 
9:00 am - 12:00 pm Breakout Group Presentations
 
12:00 pm - 1:00 pm Day 4 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 1:30 pm Closing and next steps
 
1:30 pm - 5:00 pm Optional additional Working Group Sessions (for those staying that afternoon)




  • Resources
  • A Major Role of the Macrophage in Quantitative Genetic Regulation of Immunoresponsiveness and Antiinfectious Immunity
  • Correlation between genetic regulation of immune responsiveness and host defence against infections and tumours
  • Genetic control of immune responsiveness, aging and tumor incidence
  • Genetic control of immune responsiveness, aging and tumor incidence
  • Genetic regulation of the specific and non-specific component of immunity
  • Inheritance of immune responsiveness, life span, and disease incidence in interline crosses of mice selected for high or low multispecific antibody production.
  • Life-Span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness
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