Santa Fe
Institute

Aging and Adaptation in Infectious Diseases

Thursday, July 26, 2018
8:30 am - 9:00 am Day 1 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 9:15 am Welcome - Amy P Chen (SFI), David Krakauer (SFI), Susan Fitzpatrick (JSMF) 
 
9:15 am - 9:30 am Introductions and Workshop Overview - Jean Carlson (UCSB), Mercedes Pascual (Univ. Chicago)
 
9:30 am - 11:30 am Session I: Immune System Dynamics and Age - Mercedes Pascual (Univ. Chicago)
 
  1. Host heterogeneity in susceptibility to infectious and inflammatory diseases across the lifespan - Andrea L. Graham (Princeton) 
  2. Infection trajectories through time and age - David Schneider (Stanford)
  3. Theoretical Immunology: Aging - Alan Perelson (LANL/SFI) 
11:30 am - 1:00 pm Day 1 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 3:00 pm Session IIA: Viral Evolution, Dynamics, and Therapies - Jean Carlson (UCSB)
 
  1. How to hit HIV where it hurts, with a splash of how the immune system ages - Arup K. Charaborty (MIT)
  2. Evolving antibody repertoire to vaccine and virus: evolutionary arms race and ecological feedback - Shenshen Wang (UCLA) 
  3. Aging and immunity to influenza - Sarah Cobey (Univ. Chicago)
3:00 pm - 3:30 pm Day 1 PM Break
 
3:30 pm - 5:00 pm Session IIB: Viral Evolution, Dynamics, and Therapies - Sarah Cobey (Univ. Chicago)
 
  1. Do viruses age? Temporal trends in endemically circulating viruses - Katia Koelle (Emory Univ.) 
  2. Evolution of life-history trade-offs in viruses andin virotherapy - Paul Turner (Yale)
6:30 pm Day 1 Group Dinner at La Choza
 
Friday, July 27, 2018
8:30 am - 9:00 am Day 2 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 9:30 am SFI/JSMF Aging, Adaptation, and the Arrow of Time Research Theme; Overview - Jean Carlson (UCSB), Mercedes Pascual (Univ. Chicago), David Krakauer (SFI), Susan Fitzpatrick (JSMF)

How does our working group interface with overarching goals of the research program
9:30 am - 11:30 am Session III: Host Pathogen (co)Adaptation, Diversification, and Age - Andrea L. Graham (Princeton)
 
  1. Robustness and fragility in adaptive immunity: Immunosenescence and host-pathogen coevolution - Jean Carlson (UCSB)
  2. Time, adaptation and host specialization in host-parasite interactions - Noah K. Whiteman (UC Berkeley) 
  3. Parasite (antigenic) diversity and ‘old’ and resilient transmission systems - Mercedes Pascual (Univ. Chicago) 
11:30 am - 1:00 pm Day 2 Lunch (outside SFI Noyce Conference Room)
 
1:00 pm - 3:00 pm Session IV: Complex Rhythms, environment, and aging in epidemiology - David Schneider (Stanford)
 
  1. Social gradients in nonhuman primates: linking social status to immune gene regulation - Jenny Tung (Duke Univ.) 
  2. Infectious diseases across scales, circadian rhythms: Anticipating Complex Time - Micaela Martinez (Columbia Univ.)
  3. Insights into aging and pathogens from allometrically scaled models for host-parasite systems - Andrew P. Dobson (Princeton)
3:00 pm - 3:30 pm Day 2 PM Break
 
3:30 pm - 5:00 pm Discussion, development of themes, and organization of breakout groups
 
6:30 pm Day 2 Group Dinner at Restaurant Martin
 
Saturday, July 28, 2018
8:30 am - 9:00 am Day 3 Continental Breakfast (outside SFI Noyce Conference Room)
 
9:00 am - 11:00 am Breakout Group Discussions
 
11:00 am - 12:00 pm Group Presentations and Plans for Next Steps
 
12:00 pm - 1:00 pm Day 3 Lunch (outside SFI Noyce Conference Room); Adjourn