Gillespie, Darria Long; Lauren Ancel Meyers; Michael Lachmann; Stephen C Redd and Jonathan M. Zenilman

In 2020, U.S schools closed due to SARS-CoV-2 but their role in transmission was unknown. In fall 2020, national guidance for reopening omitted testing or screening recommendations. We report the experience of 2 large independent K-12 schools (School-A and School-B) that implemented an array of SARS-CoV-2 mitigation strategies that included periodic universal testing.